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Glossary

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Important words to know and understand

A

Abnormal

Different from what is considered normal.

Antibodies

Proteins made by the immune system that help find and fight infections.

B

Bone marrow

Soft tissue found inside your bones.

C

CELMoD

A CELMoD is a new class* of medicine that helps boost your immune system's ability to fight multiple myeloma.

 

*New class: cereblon modulating protein degrader.

Complete response

When all signs of cancer have disappeared after treatment. This is not the same as a cure.

D

Dose

The amount of medicine given to a patient.

F

First-line treatment

The first treatment or combination of treatments that a doctor recommends for a disease.

I

Immune system

The body’s natural defense system that helps fight infections and disease.

M

M proteins

Abnormal proteins made by myeloma cells that can be found in the blood.

Maintenance therapy

Ongoing treatment given after initial therapy to help keep disease under control.

Median

Median is the middle number in a group of numbers arranged from lowest to highest.

Minimal residual disease (MRD)

A special test used in clinical studies to look for very small amounts of myeloma cells after treatment. If you are MRD negative, no myeloma cells were found in the sample tested. MRD negativity is not the same as a cure.

Multiple myeloma (MM)

A disease where plasma cells become cancerous and grow out of control.

Myeloma cells

Abnormal plasma cells.

P

Plasma cells

White blood cells that make substances which fight infections.

R

Refractory

The cancer isn’t responding to treatment.

Relapse

When cancer comes back after responding to treatment.

Remission

When the signs and symptoms of cancer have reduced or disappeared after treatment. It’s important to know that this is not the same as a cure.

REMS

Risk Evaluation and Mitigation Strategy. A special FDA-required safety program for certain medicines. It helps protect patients by making sure they understand the risks and how to use the medicine safely. Your healthcare team will guide you through this process.

S

Second-line treatment

Treatment or combination of treatments given if the cancer comes back (relapsed) or stops responding to treatment (refractory).

Side effect

An unintended reaction to, or result of, a treatment.

Stem cell transplant (SCT)

A procedure that replaces abnormal stem cells with healthy stem cells.

W

White blood cells

Cells in the blood that help fight infection.

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Results with ZENBEXUS

ZENBEXUS is approved for adult use only.
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